This document is a contribution of the Economic Commission for Latin America and the Caribbean (ECLAC) to the information collection and the deliberations of the “XVII Summit of Heads of State and Government of the Tuxtla Mechanism of Dialogue and Cooperation.” ECLAC, as a member of the Interinstitutional Technical Group, ratifies its commitment with regional integration. Furthermore, this third edition of the document “A glance at member countries of the Mesoamerica Integration and Development Project” (2012 and 2015), underlines its support for the integration and development activities carried out by the Mesoamerica Integration and Development Project (MP). This view offers a concise panorama of the economic, social and environmental reality of the Mesoamerican region. The document summarizes the main challenges and opportunities found in the different components of the MP portfolio: economic development; trade and investment; competitiveness, small and medium enterprises and information and communication technologies; logistics and mobility; energy; health; nutrition and food security; housing; and environment, disaster risk management and climate change. These challenges can be tackled more easily through regional coordination and cooperation and are reminders of the importance of coordinating strategies with regional integration institutions and national policies.