The COVID-19 crisis has hit Latin America and the Caribbean harder than any other developing region. In 2020 the regional GDP will experience its greatest decline in 120 years. The pandemic represents a formidable social challenge, exposing all the regions’ endemic problems. Against this backdrop, this paper analyses the Multilateral Development Banks (MDBs) response to the COVID-19 crisis and their post-pandemic role and prospects in LAC. Some basic information is presented on the major MDBs that serve the region and their main trends during the last decade to provide an adequate context.